US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Is it safe to take Zofran while pregnant?
Taking Zofran while pregnant is low risk, and it has been prescribed for years for pregnancy nausea. That said, Zofran for pregnancy nausea is an off-label use, and there may be better options.
Is Zofran safe at 11 weeks pregnant?
A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.
What kind of drug is Zofran?
Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.
Is ondansetron safe in early pregnancy?
Ondansetron. Although ondansetron has limited safety data in pregnancy, it is often prescribed for women with hyperemesis gravidarum. It is not recommended as first-line therapy, especially in the first trimester of pregnancy. Ondansetron commonly causes constipation, which may already be a problem in pregnancy.
Will taking Zofran hurt my baby?
If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small. As always, I encourage you to ask questions.
Is Zofran really linked to birth defects?
The results of these studies have concluded Zofran causes birth defects, particularly congenital heart defects, cleft palate defects, and kidney defects. The birth defects linked to use of Zofran during pregnancy include: 130% risk of overall birth defects. 620% risk of kidney obstruction birth defects.
Can Zofran cause miscarriage?
Currently, no scientific evidence has linked the anti-nausea drug Zofran, frequently prescribed “off-label” for morning sickness, to an increased risk of miscarriage.
What nausea medicine is safe while pregnant?
In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.
Is metoclopramide safe in first trimester?
In this large, population-based cohort, we found no significant association between metoclopramide treatment in the first trimester and adverse outcomes for the fetus, including congenital malformations, perinatal death, low birth weight, and low Apgar scores.
Who should not take Zofran?
You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Is Zofran used for anxiety?
Zofran (ondansetron) and Compazine (prochlorperazine) are prescribed for the treatment of nausea and vomiting. Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery. Compazine is also used to treat psychotic disorders such as schizophrenia and anxiety.
How quickly does Zofran work?
Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran’s effects can last 8 to 12 hours. The Zofran dosage varies depending on the severity and cause of the nausea and vomiting.
What is the safest antiemetic for pregnancy?
Motion sickness drugs like meclizine and dimenhydrinate are safe for pregnant women. Vitamin B-6 and dopamine antagonists have been found to be safe, but are only used in severe cases of morning sickness.
How often can you take Zofran 8 mg while pregnant?
Ondansetron can be given orally or intravenously in doses up to 8 mg three to four times daily.