What antihypertensives are contraindicated in pregnancy?

ACE-Is and angiotensin receptor blockers should be avoided in all trimesters; when administered in the second and third trimesters, they are associated with a characteristic fetopathy, neonatal renal failure, and death, and, thus, are contraindicated.

Which antihypertensive is not safe in pregnancy?


Table 1 Antihypertensive drugs to avoid in pregnancy and preconception
ACE inhibitors Contraindicated
Angiotensin receptor blockers Contraindicated
Diuretics Avoid

Why is amlodipine contraindicated in pregnancy?

Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

Which hypertensive drug is safe in pregnancy?

According to NHBPEP methyldopa, labetalol, beta blockers (other than atenolol), slow release nifedipine, and a diuretic in pre-existing hypertension are considered as appropriate treatment [1].

Why ACE inhibitors are contraindicated in pregnancy?

It is well accepted that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during the second and third trimesters of pregnancy because of increased risk of fetal renal damage. First-trimester use, however, has not been linked to adverse fetal outcomes.

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Are beta-blockers contraindicated in pregnancy?

(10-14) However, beta-blockers cross the placental barrier and are associated with several adverse effects, such as delayed intrauterine growth, respiratory depression, neonatal bradycardia and hypoglycemia, particularly when treatment is started early on in the pregnancy (i.e. at 12–24 weeks).

Why diuretics are contraindicated in pregnancy?

Diuretics given after the first trimester interfere with normal plasma volume expansion, which may exacerbate the volume depletion in pre-eclampsia and cause intrauterine growth retardation [3]. Diuretics have not been reported to have teratogenic effects.

Is metoprolol safe in pregnancy?

Metoprolol did not cause birth defects when given to animals early in pregnancy. A study of a large number of pregnancies found that beta-blockers did not cause heart defects in babies. Does taking metoprolol cause other pregnancy complications? Metoprolol has been associated with reduced growth of the baby.

What are the contraindications of amlodipine?

Who should not take AMLODIPINE BESYLATE?

  • severe narrowing of the aortic heart valve.
  • significantly low blood pressure.
  • severe liver disease.

Is labetalol safe in pregnancy?

If you’re pregnant, labetalol is the first choice for treating high blood pressure. Labetalol works on the heart and on blood vessels. Other beta blockers, such as bisoprolol, work mainly on the heart. There are several other medicines to lower blood pressure and treat chest pain.

Why Alpha methyldopa is safe in pregnancy?

Methyldopa crosses the placenta, and may cause mild hypotension in neonates of treated mothers. Because it has been safely and successfully used to treat hypertension during pregnancy, some experts consider it to be the drug of choice for the treatment of nonemergent hypertension during pregnancy.

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Can you have a natural birth with high blood pressure?

It’s possible to have a vaginal birth if you have high blood pressure, even if you develop superimposed preeclampsia. But it’s very likely that your labor will be induced. It’s also likely that you’ll need to deliver by cesarean section (c-section).

What is chronic hypertension in pregnancy?

Chronic hypertension in pregnancy is defined by the American College of Obstetrics and Gynecology (ACOG) as blood pressure ≥140 mm Hg systolic and/or 90 mm Hg diastolic before pregnancy or, in recognition that many women seek medical care only once pregnant, before 20 weeks of gestation, use of antihypertensive …

Why is atenolol contraindicated in pregnancy?

Atenolol and Pregnancy

Atenolol can cause fetal harm when administered to a pregnant woman. Atenolol crosses the placental barrier and appears in cord blood. Atenolol use in pregnant women resulted in children born small in size with low sugar and slow heart rate.

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